Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 5-acetyl-2-chloro-6-methylnicotinonitrile | HCID 1475375 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 1471731 | HCID 1471731 | — |
Reaction Steps
9.5 g (48.8 mmol) of 3-acetyl-6-chloro-5-cyano-2-methyl-pyridine are dissolved in 180 ml of toluene, 9.5 g (0.109 mol) of morpholine are added, and the mixture is stirred at 90° C. for two hours. To work up, the mixture is evaporated, and the residue is suspended in water, filtered with suction and carefully washed with water. Re-crystallization from methanol/water is used for purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04920136 |
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| Source dataset | uspto-grants-1990_04 |
|---|
| ORD ID | ord-5d5bc7643f544456ae4125dbf90c803d |
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| Source note | uspto-grants-1990_04 |
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