HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Ethyl 2-(2-(3-((quinolin-2-yl)methyloxy)phenoxymethyl)phenoxy)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Phenol, 3-(2-quinolinylmethoxy)- | HCID 10988736 | — |
| Reactant | Ethyl 2-(2-bromomethylphenoxy)propionate | HCID 11808300 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 2-(2-(3-((quinolin-2-yl)methyloxy)phenoxymethyl)phenoxy)propionate | HCID 11113252 | — |
Reaction Steps
To a solution of (5.23 mmol) of 3-(quinolin-2-yl)methyloxyphenol and (5.23 mmol) of the bromide from step B in 90 ml of 8:1--acetone:DMF is added 1.52 g (10.97 mmol, 2.1 equiv) of K2CO3. The mixture is refluxed overnight, then partitioned between EtOAc and H2O. The organics are dried, filtered, and concentrated in vacuo. This is then purified by flash column chromatography to give ethyl 2-(2-(3-((quinolin-2-yl)methyloxy)phenoxymethyl)phenoxy)propionate which is used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04920131 |
| Source dataset | uspto-grants-1990_04 |
| ORD ID | ord-ae4cb130ac5740f383aa6d9a5efaa0b5 |
| Source note | uspto-grants-1990_04 |