HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Ethyl 2-(3-(2-(3-(2-quinolinylmethyloxy)phenyl)-2-(carbethoxyethylthio)ethyl)phenoxy)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl 3-mercaptopropionate | HCID 21625 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Ethyl 2-(3-(2-(3-(2-quinolinylmethyloxy)phenyl)-2-hydroxyethyl)phenoxy)acetate | HCID 14774138 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 2-(3-(2-(3-(2-quinolinylmethyloxy)phenyl)-2-(carbethoxyethylthio)ethyl)phenoxy)acetate | HCID 14774139 | — |
Reaction Steps
The product obtained from Step C in 50 mL of CH2Cl2 is treated with 2 mL of SOCl2. The reaction mixture is stirred at room temperature for 2 hr. and then evaporated to dryness. The crude product thus obtained in 20 mL of CH2Cl2 is treated with ethyl 3-mercaptopropionate and triethylamine (1:1) for 16 hr. at room temperature. After evaporation of solvent, the crude product is purified by flash column chromatography to obtain ethyl 2-(3-(2-(3-(2-quinolinylmethyloxy)phenyl)-2-(carbethoxyethylthio)ethyl)phenoxy)acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04920131 |
| Source dataset | uspto-grants-1990_04 |
| ORD ID | ord-3f407f963e5e4525a20197cbeb3b659a |
| Source note | uspto-grants-1990_04 |