Hydrogen Peroxide → Pyridine, 2,3-dimethyl-, 1-oxide

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Reaction Steps

2,3-Dimethylpyridine(40g) was dissolved in glacial acetic acid(80ml). To the solution was added 35% hydrogen peroxide(46.5g), and the mixture was heated at 100°-110° C. to be reacted under reflux with stirring for 3 hours. After the reaction, to the reaction solution was added pformaldehyde(1.5 g); the mixture was heated at 100°-105° C. to decompose the residual hydrogen peroxide and then was concentrated to give 2,3-dimethylpyridine-1-oxide.

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