Hydrogen Peroxide → Pyridine, 2,3-dimethyl-, 1-oxide

HRID 2073959Notes

Reaction equation

HRID 2073959 reaction equation
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[OH:9]O>C(O)(=O)C>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][N+:3]=1[O-:9]

Participants

4

Reactant 2

HCID 784Hydrogen Peroxide2×HCID 114202,3-Lutidine

Product 1

HCID 3840573Pyridine, 2,3-dimethyl-, 1-oxide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2,3-Dimethylpyridine(40g) was dissolved in glacial acetic acid(80ml). To the solution was added 35% hydrogen peroxide(46.5g), and the mixture was heated at 100°-110° C. to be reacted under reflux with stirring for 3 hours. After the reaction, to the reaction solution was added pformaldehyde(1.5 g); the mixture was heated at 100°-105° C. to decompose the residual hydrogen peroxide and then was concentrated to give 2,3-dimethylpyridine-1-oxide.

Workup

  1. temperaturethe mixture was heated at 100°-110° C.
  2. customto be reacted
  3. temperatureunder reflux
  4. customAfter the reaction
  5. additionto the reaction solution was added pformaldehyde(1.5 g)
  6. temperaturethe mixture was heated at 100°-105° C.
  7. concentrationwas concentrated

Sources & evidence

ORD record
ord-97a9d9977f2b422799cc054f703d77be
Source dataset
uspto-grants-1990_04
Patent number
US04920230

Reaction notes

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