反应详情

The mixture of the indole of step 8 above (0.9 g) and Pt-C (0.2 g), acetic acid and MeOH (100 ml) is stirred under H2 at 1 atm. pressure for 48 hours. The catalyst is filtered (celite), the filtered material is washed (MeOH) and the reaction mixture and methanol washings are evaporated. The residue is diluted with CH2Cl2, washed with saturated NaHCO3, dried (MgSO4) and evaporated affording a colorless, semicrystalline material which is determined to be the desired compound by NMR. M.P. 107°-109° C.

1. filtrationThe catalyst is filtered (celite)
2. washthe filtered material is washed (MeOH)
3. customthe reaction mixture and methanol washings are evaporated
4. additionThe residue is diluted with CH2Cl2
5. washwashed with saturated NaHCO3
6. dry with materialdried (MgSO4)
7. customevaporated
8. customaffording a colorless, semicrystalline material which