1-Acetyl-5-carbomethoxy-7-chloro-4-methoxy-1,2-dihydroindole → 1-Acetyl-5-carboxy-7-chloro-4-methoxy-1,2-dihydroindole

Participants

Reaction Steps

A mixture of the indole ester of step 9 above (0.8 g) and 10% aqueous NaOH/MeOH (20 ml/80 ml) is stirred under reflux for 2 hours. The reaction mixture is concentrated and the aqueous residue is diluted with water and extracted with CHCl3. The organic layer is dried (MgSO4) and evaporated affording an off-white solid which is determined to be the desired compound by NMR.

Provenance & Evidence