Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Allyl bromide | HCID 7841 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 4-amino-5-chloro-2-hydroxybenzoate | HCID 14883223 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 14883224 | HCID 14883224 | — |
Reaction Steps
A mixture of methyl 4-amino-5-chlorosalicylate (5 g), allyl bromide (12.6 g), ground K2CO3 (30 g) and acetone (120 ml) is stirred at reflux for 5 hours and cooled to 25° C. The mixture is partitioned between methylene chloride and H2O, the organic layer is separated, dried (MgSO4), filtered and evaporated. The residue is recrystallized from hexanechloroform affording the desired product as a crystalline solid (M.P. 107°-109° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04920219 |
|---|
| Source dataset | uspto-grants-1990_04 |
|---|
| ORD ID | ord-8f61c748080244508856580fd740e409 |
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| Source note | uspto-grants-1990_04 |
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