反应详情

温度

25 °C

A mixture of methyl 4-amino-5-chlorosalicylate (5 g), allyl bromide (12.6 g), ground K2CO3 (30 g) and acetone (120 ml) is stirred at reflux for 5 hours and cooled to 25° C. The mixture is partitioned between methylene chloride and H2O, the organic layer is separated, dried (MgSO4), filtered and evaporated. The residue is recrystallized from hexanechloroform affording the desired product as a crystalline solid (M.P. 107°-109° C.).

1. temperatureat reflux for 5 hours
2. customThe mixture is partitioned between methylene chloride and H2O
3. customthe organic layer is separated
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. customevaporated
7. customThe residue is recrystallized from hexanechloroform