H-152/81 → 2,6-Dimethyl-3-carbomethoxy-4-(2-chlorophenyl)-5-carboxy-1,4-dihydropyridine

HRID 2074032Notes

Reaction equation

HRID 2074032 reaction equation
[CH3:1][C:2]1[NH:3][C:4]([CH3:23])=[C:5]([C:20]([OH:22])=[O:21])[CH:6]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14](Cl)[C:13]=2[Cl:19])[C:7]=1[C:8]([O:10][CH3:11])=[O:9]>CN(C=O)C>[CH3:1][C:2]1[NH:3][C:4]([CH3:23])=[C:5]([C:20]([OH:22])=[O:21])[CH:6]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:19])[C:7]=1[C:8]([O:10][CH3:11])=[O:9]

Participants

3

Reactant 1

HCID 2794058H-152/81

Product 1

HCID 130691652,6-Dimethyl-3-carbomethoxy-4-(2-chlorophenyl)-5-carboxy-1,4-dihydropyridine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

(--2,6-dimethyl-3-carbomethoxy-4-(2,3-dichlorophenyl)-5-carboxy-1,4-dihydropyridine, mp=225° C., [α]D20 =-28.5°, c=5, DMF;

Sources & evidence

ORD record
ord-167ef3dd138f47b5b6d8c978c5b5a477
Source dataset
uspto-grants-1990_04
Patent number
US04920225

Reaction notes

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