Ethyl 1-methyl-4-nitroimidazole-2-carboxylate → ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate

Participants

Reaction Steps

0.50 g (2.5 mmol) of ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate are dissolved in 7.5 ml of ethanol, 0.13 g (0.13 mmol) of palladium-on-carbon (10%) are added and the mixture is hydrogenated at 3 bar for 12 h. The reaction solution is then filtered through kieselguhr and the filtrate is concentrated. The residue is dried in vacuo and reacted further without further purification.

Provenance & Evidence