反应详情

3.47 g (12.5 mmol) of 1-(tert-butyloxycarbonyl)-4-(5-methylpyridin-2-yl)piperazine are dissolved in 10 ml of dioxane, and 31 ml (125 mmol) of hydrogen chloride in dioxane (4 molar) are added. The mixture is stirred at RT for 2 h. The mixture is then concentrated and the residue is rendered alkaline using a 1M aqueous sodium hydroxide solution and extracted several times with dichloromethane. The combined organic phases are dried over sodium sulfate, concentrated and dried in vacuo.

1. concentrationThe mixture is then concentrated
2. extractionextracted several times with dichloromethane
3. dry with materialThe combined organic phases are dried over sodium sulfate
4. concentrationconcentrated
5. customdried in vacuo