Methanol → HCID 57869857, compound

HRID 20741Notes

Reaction equation

HRID 20741 reaction equation
CO[C:3](=[O:13])[CH2:4][CH2:5][O:6][N:7]=[C:8]([O:10][CH2:11][CH3:12])[CH3:9].[CH3:14][NH2:15].[CH3:16]O>>[CH2:11]([O:10][C:8](=[N:7][O:6][CH2:5][CH2:4][C:3](=[O:13])[NH:15][CH2:14][CH3:16])[CH3:9])[CH3:12]

Participants

4

Reactant 3

HCID 887MethanolHCID 6329MethylamineHCID 71331645Methyl 3-{[(1-ethoxyethylidene)amino]oxy}propanoate

Product 1

HCID 57869857HCID 57869857, compoundYield 57%

Conditions

Temperature
60 °C

Procedure

To a known compound, 3-(1-ethoxyethylideneaminooxy)-propanoic acid methyl ester (CAS No. 97164-30-2, 300 mg, 1.585 mmol) was added a 2 M solution of methylamine in methanol (7 ml), and the mixture was stirred at 60° C. for 13 hours. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to give N-(2-ethylcarbamoyl-ethoxy)-acetimidic acid ethyl ester (182 mg, 57% yield).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-d04505c9822a4c8b80b3167846521152
Source dataset
uspto-grants-2010_06
Patent number
US07745663B2

Reaction notes

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