反应详情

To a solution of N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-1,2,3-triazole-4-carboxamide (8.0 g, 0.03 mol) in anhydrous THF (75 mL) was added dropwise methyl magnesium bromide (3.0 M in hexane, 20 mL, 0.058 mol) at 0° C. After the addition, the mixture was stirred at RT overnight. The mixture was quenched with sat. aq. NH4Cl (30 mL) then extracted with CH2Cl2 (3×50 mL). The organics were combined, washed with 1 N aq. NaOH (3×20 mL), water (3×20 mL), brine (50 mL), dried over MgSO4 and evaporated to yield the title compound (8.0 g, 75.0%) as a white solid.

1. additionAfter the addition
2. customThe mixture was quenched with sat. aq. NH4Cl (30 mL)
3. extractionthen extracted with CH2Cl2 (3×50 mL)
4. washwashed with 1 N aq. NaOH (3×20 mL), water (3×20 mL), brine (50 mL)
5. dry with materialdried over MgSO4
6. customevaporated