Methanol → HCID 178502570, compound

HRID 2074201Notes

Reaction equation

HRID 2074201 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][C:7](=[O:25])[N:8]2[C@H:11]2[CH2:16][CH2:15][C@H:14](C3N(C([O-])=O)C=CN=3)[CH2:13][CH2:12]2)=[C:4]([Cl:26])[N:3]=1.[C:27](=[O:30])([O-:29])[O-:28].[K+].[K+].[CH3:33]O>>[C:27](=[O:29])([O:28][CH3:33])[O:30][C@H:14]1[CH2:13][CH2:12][C@H:11]([N:8]2[C:7](=[O:25])[NH:6][C:5]3[C:9]2=[N:10][C:2]([NH2:1])=[N:3][C:4]=3[Cl:26])[CH2:16][CH2:15]1

Participants

4

Reactant 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 178508436HCID 178508436, compound

Product 1

HCID 178502570HCID 178502570, compound

Procedure

To a suspension of trans-4-(2-amino-6-chloro-8-oxo-7,8-dihydropurin-9-yl)cyclohexyl-1H-imidazole-1-carboxylate (10.6 g, 28.1 mmol) in anhydrous methanol (400 mL) was added potassium carbonate (1.1 g, 10% wt) with stirring at room temperature. After 15 h, the reaction was found to be complete by LC-MS. The solvent was removed in vacuo, and water (1 L) was added with stirring at room temperature. Filtration under vacuum gave the desired product as a pink solid (yield quantitative). MS (EI) m/z 342.1 (MH)+.

Workup

  1. customThe solvent was removed in vacuo, and water (1 L)
  2. additionwas added
  3. stirringwith stirring at room temperature
  4. filtrationFiltration under vacuum

Sources & evidence

ORD record
ord-aa897e0a1b7a413ba2f7197cca164eb3
Source dataset
uspto-grants-2011_04
Patent number
US07919490B2

Reaction notes

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