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HRID2074208

反应详情

EQUATION

反应方程式

HRID 2074208 的结构方程式

REACTANTS

反应物

2
结构：Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1
HCID466102

未命名化合物

结构：Cn1c(=O)n([C@H]2CC[C@H](OC3CCCCO3)CC2)c2nc(-n3cnc4ccc(F)cc43)nc(Cl)c21
HCID178481615

未命名化合物

PRODUCTS

生成物

1
结构：Cn1c(=O)n([C@H]2CC[C@H](O)CC2)c2nc(-n3cnc4ccc(F)cc43)nc(Cl)c21
HCID178481617

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO.O
溶剂HCID19096565

未命名化合物

PROCEDURE

实验过程

A solution of 6-chloro-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-7-methyl-9-(trans-4-(tetrahydro-2H-pyran-2-yloxy)cyclohexyl)-7H-purin-8(9H)-one (0.06 mmol) and PPTS (5 mg) in ethanol/water (4.5 mL/0.5 mL) was stirred at reflux for 1 h. The solvent was evaporated in vacuo and the residue could be purified by chromatography or used in the next step without purification. MS (EI) m/z 417.0 (MH)+.

WORKUP

后处理

  1. temperatureat reflux for 1 h
  2. customThe solvent was evaporated in vacuo
  3. customthe residue could be purified by chromatography
  4. customused in the next step without purification