Hydrogen chloride-ethyl acetate → HCID 57421796, compound

HRID 2074232Notes

Reaction equation

HRID 2074232 reaction equation
[CH:1]1([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([S:15]([CH:18]3[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]3)(=[O:17])=[O:16])=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:31].CCOC(C)=O>CCOC(C)=O>[ClH:31].[CH:1]1([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([S:15]([CH:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)(=[O:16])=[O:17])=[CH:11][CH:10]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57507754HCID 57507754, compound

Product 1

HCID 57421796HCID 57421796, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The resulting tert-butyl 4-{[4-(cyclohexylmethoxy)phenyl]sulfonyl}piperidine-1-carboxylate (635 mg) was dissolved in EtOAc (7 ml), and a 4 M hydrogen chloride/EtOAc solution (3.6 ml) was added thereto, followed by stirring at room temperature for 6 hours. The solid was collected by filtration and washed with EtOAc to obtain 4-{[4-(cyclohexylmethoxy)phenyl]sulfonyl}piperidine hydrochloride (485 mg) as colorless powder.

Workup

  1. filtrationThe solid was collected by filtration
  2. washwashed with EtOAc

Sources & evidence

ORD record
ord-0b43bebe838847fc93e3242bdebeb6c1
Source dataset
uspto-grants-2011_04
Patent number
US07919494B2

Reaction notes

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