Hydrogen chloride-ethyl acetate → 1-{3-[2-(4-Piperidinyl)ethyl]phenyl}urea hydrochloride

HRID 2074254Notes

Reaction equation

HRID 2074254 reaction equation
[ClH:1].CCOC(C)=O.[NH2:8][C:9]([NH:11][C:12]1[CH:13]=[C:14]([CH2:18][CH2:19][CH:20]2[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]2)[CH:15]=[CH:16][CH:17]=1)=[O:10]>CCOC(C)=O>[ClH:1].[NH:23]1[CH2:22][CH2:21][CH:20]([CH2:19][CH2:18][C:14]2[CH:13]=[C:12]([NH:11][C:9]([NH2:8])=[O:10])[CH:17]=[CH:16][CH:15]=2)[CH2:25][CH2:24]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57507767Tert-butyl 4-(2-{3-[(aminocarbonyl)amino]phenyl}ethyl)-1-piperidinecarboxylate

Product 1

HCID 574218381-{3-[2-(4-Piperidinyl)ethyl]phenyl}urea hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4 M hydrogen chloride/EtOAc (4 ml) was added to an EtOAc (9 ml) solution of tert-butyl 4-(2-{3-[(aminocarbonyl)amino]phenyl}ethyl)-1-piperidinecarboxylate (227 mg), followed by stirring at room temperature for 3 hours. The solvent was evaporated under reduced pressure to obtain 1-{3-[2-(4-piperidyl)ethyl]phenyl}urea hydrochloride (185 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-437f68b5e2884b729e11b2c051d749f5
Source dataset
uspto-grants-2011_04
Patent number
US07919494B2

Reaction notes

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