Sodium Hydroxide → Sodium 5-{[(4-{2-[1-(6-methylpyridin-2-yl)piperidin-4-yl]ethyl}piperidin-1-yl)carbonyl]oxy}nicotinate

HRID 2074285Notes

Reaction equation

HRID 2074285 reaction equation
[OH-].[Na+:2].[CH3:3][C:4]1[N:9]=[C:8]([N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][CH2:17][CH:18]3[CH2:23][CH2:22][N:21]([C:24]([O:26][C:27]4[CH:28]=[N:29][CH:30]=[C:31]([CH:36]=4)[C:32]([O:34]C)=[O:33])=[O:25])[CH2:20][CH2:19]3)[CH2:12][CH2:11]2)[CH:7]=[CH:6][CH:5]=1>C1COCC1>[CH3:3][C:4]1[N:9]=[C:8]([N:10]2[CH2:11][CH2:12][CH:13]([CH2:16][CH2:17][CH:18]3[CH2:23][CH2:22][N:21]([C:24]([O:26][C:27]4[CH:28]=[N:29][CH:30]=[C:31]([CH:36]=4)[C:32]([O-:34])=[O:33])=[O:25])[CH2:20][CH2:19]3)[CH2:14][CH2:15]2)[CH:7]=[CH:6][CH:5]=1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57507820Methyl 5-{[(4-{2-[1-(6-methylpyridin-2-yl)piperidin-4-yl]ethyl}piperidin-1-yl)carbonyl]oxy}nicotinate

Product 1

HCID 67067083Sodium 5-{[(4-{2-[1-(6-methylpyridin-2-yl)piperidin-4-yl]ethyl}piperidin-1-yl)carbonyl]oxy}nicotinate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

An aqueous 1 M sodium hydroxide solution (0.45 ml) was added to a THF (5 ml) solution of methyl 5-{[(4-{2-[1-(6-methylpyridin-2-yl)piperidin-4-yl]ethyl}piperidin-1-yl)carbonyl]oxy}nicotinate (208 mg), followed by stirring overnight at room temperature. The reaction liquid was concentrated to obtain sodium 5-{[(4-{2-[1-(6-methylpyridin-2-yl)piperidin-4-yl]ethyl}piperidin-1-yl)carbonyl]oxy}nicotinate (158 mg).

Workup

  1. customThe reaction liquid
  2. concentrationwas concentrated

Sources & evidence

ORD record
ord-35bdb0f84a9d4aba9577ace6d9630558
Source dataset
uspto-grants-2011_04
Patent number
US07919494B2

Reaction notes

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