Hydrogen chloride-ethyl acetate → HCID 57507762, compound

HRID 2074303Notes

Reaction equation

HRID 2074303 reaction equation
[ClH:1].CCOC(C)=O.[CH3:8][C:9]1[N:14]=[C:13]([N:15]2[CH2:20][CH2:19][CH:18]([CH2:21][CH2:22][CH2:23][CH:24]3[CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26][CH2:25]3)[CH2:17][CH2:16]2)[CH:12]=[CH:11][CH:10]=1>CCOC(C)=O>[ClH:1].[ClH:1].[CH3:8][C:9]1[CH:10]=[CH:11][CH:12]=[C:13]([N:15]2[CH2:20][CH2:19][CH:18]([CH2:21][CH2:22][CH2:23][CH:24]3[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]3)[CH2:17][CH2:16]2)[N:14]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57507761HCID 57507761, compound

Product 1

HCID 57507762HCID 57507762, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4 M hydrogen chloride/EtOAc (10 ml) was added to an EtOAc (25 ml) solution of tert-butyl 4-{3-[1-(6-methyl-2-pyridinyl)-4-piperidinyl]propyl}-1-piperidinecarboxylate (1.3 g), followed by stirring overnight at room temperature. The reaction liquid was concentrated, then 2-propanol/diethyl ether was added thereto, followed by stirring. The precipitated solid was collected by filtration, and dried under reduced pressure to obtain 2-methyl-6-{4-[3-(4-piperidinyl)propyl]-1-piperidyl}pyridine dihydrochloride (1.1 g).

Workup

  1. customThe reaction liquid
  2. concentrationwas concentrated
  3. addition2-propanol/diethyl ether was added
  4. stirringby stirring
  5. filtrationThe precipitated solid was collected by filtration
  6. customdried under reduced pressure

Sources & evidence

ORD record
ord-406de24173b04e5c8454220776a1d59c
Source dataset
uspto-grants-2011_04
Patent number
US07919495B2

Reaction notes

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