HCID 57507805, compound → HCID 57507806, compound

HRID 2074330Notes

Reaction equation

HRID 2074330 reaction equation
C([O:8][C:9]1[CH:33]=[CH:32][C:12]([O:13][CH:14]2[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]3[CH:24]=[N:25][CH:26]=[C:27]([CH:31]=3)[C:28]([OH:30])=[O:29])=[O:21])[CH2:16][CH2:15]2)=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>[C].[Pd].C1COCC1>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([O:13][CH:14]2[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]3[CH:24]=[N:25][CH:26]=[C:27]([CH:31]=3)[C:28]([OH:30])=[O:29])=[O:21])[CH2:16][CH2:15]2)=[CH:32][CH:33]=1

Participants

5

Reactant 2

HCID 57507805HCID 57507805, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 57507806HCID 57507806, compoundYield 34.4%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

10% Palladium-carbon (catalytic amount) was added to a THF (10 ml) solution containing 5-[({4-[4-(benzyloxy)phenoxy]piperidin-1-yl}carbonyl)oxy]nicotinic acid (200 mg), and in a hydrogen gas atmosphere, this was stirred at room temperature under normal pressure for 3 hours. The catalyst was removed by filtration, and the resulting filtrate was concentrated under reduced pressure to obtain 5-[({4-[4-(hydroxy)phenoxy]piperidin-1-yl}carbonyl)oxy]nicotinic acid (55 mg).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe resulting filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-6f56b07944014ac486dd7fe8dbf696b8
Source dataset
uspto-grants-2011_04
Patent number
US07919495B2

Reaction notes

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