HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2074332Generated: October 31, 2026
1,4-Dioxane hydrochloride → HCID 67067111, compound
https://huagongshe.com/reaction/2074332
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | HCID 57421844 | HCID 57421844 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67067111 | HCID 67067111 | — |
Reaction Steps
A 4 M hydrogen chloride/dioxane solution (1.8 ml) was added to a THF (10 ml) solution containing 5-[(tert-butoxycarbonyl)amino]pyridin-3-yl 4-{4-[(3-fluorobenzyl)oxy]phenoxy}piperidine-1-carboxylate (174 mg), followed by stirring at 60° C. for 4 hours. The solvent was evaporated under reduced pressure to obtain 5-aminopiperidin-3-yl 4-{4-[(3-fluorobenzyl)oxy]phenoxy}pyridine-1-carboxylate hydrochloride (74 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07919495B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-7ac6c491b70b4b88ad75371e9b8e365a |
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| Source note | uspto-grants-2011_04 |
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