1,4-Dioxane hydrochloride → HCID 67067111, compound

HRID 2074332Notes

Reaction equation

[ClH:1].O1CCOCC1.[F:8][C:9]1[CH:10]=[C:11]([CH:44]=[CH:45][CH:46]=1)[CH2:12][O:13][C:14]1[CH:43]=[CH:42][C:17]([O:18][CH:19]2[CH2:24][CH2:23][N:22]([C:25]([O:27][C:28]3[CH:29]=[N:30][CH:31]=[C:32]([NH:34]C(OC(C)(C)C)=O)[CH:33]=3)=[O:26])[CH2:21][CH2:20]2)=[CH:16][CH:15]=1>C1COCC1>[ClH:1].[F:8][C:9]1[CH:10]=[C:11]([CH:44]=[CH:45][CH:46]=1)[CH2:12][O:13][C:14]1[CH:43]=[CH:42][C:17]([O:18][C:19]2[CH:20]=[CH:21][N:22]([C:25]([O:27][CH:28]3[CH2:33][CH:32]([NH2:34])[CH2:31][NH:30][CH2:29]3)=[O:26])[CH2:23][CH:24]=2)=[CH:16][CH:15]=1

Participants

Conditions

Temperature: 60 °C

Procedure

A 4 M hydrogen chloride/dioxane solution (1.8 ml) was added to a THF (10 ml) solution containing 5-[(tert-butoxycarbonyl)amino]pyridin-3-yl 4-{4-[(3-fluorobenzyl)oxy]phenoxy}piperidine-1-carboxylate (174 mg), followed by stirring at 60° C. for 4 hours. The solvent was evaporated under reduced pressure to obtain 5-aminopiperidin-3-yl 4-{4-[(3-fluorobenzyl)oxy]phenoxy}pyridine-1-carboxylate hydrochloride (74 mg).

Workup

customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record: ord-7ac6c491b70b4b88ad75371e9b8e365a
Source dataset: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07919495B2

Reaction notes

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