(S)-2-[(6,7-Difluoro-3-methylquinoxaline-2-ylamino)methyl]-piperidine-1-carboxylic acid tert butylester → (S)-2-[(6,7-Difluoro-3-methylquinoxalin-2-ylamino)methyl]-piperidine
Reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:14][NH:15][C:16]1[C:25]([CH3:26])=[N:24][C:23]2[C:18](=[CH:19][C:20]([F:28])=[C:21]([F:27])[CH:22]=2)[N:17]=1)=O)(C)(C)C>FC(F)(F)C(O)=O>[F:27][C:21]1[CH:22]=[C:23]2[C:18](=[CH:19][C:20]=1[F:28])[N:17]=[C:16]([NH:15][CH2:14][C@@H:9]1[CH2:10][CH2:11][CH2:12][CH2:13][NH:8]1)[C:25]([CH3:26])=[N:24]2Participants
3
Procedure
(S)-2-[(6,7-Difluoro-3-methylquinoxalin-2-ylamino)methyl]-piperidine-1-carboxylic acid tert butyl ester (0.524 g) was dissolved in trifluoroacetic acid (15 ml) and stirred at room temperature for 3 hours. The solution was then evaporated and the residue chromatographed over silica gel, eluting with 0 to 10% (9:1 methanol—concentrated ammonia solution) in dichloromethane. The title compound was obtained as a white solid (0.289 g), MH+ 293.
Workup
- customThe solution was then evaporated
- customthe residue chromatographed over silica gel
- washeluting with 0 to 10% (9:1 methanol—concentrated ammonia solution) in dichloromethane
Sources & evidence
- ORD record
- ord-b6fcca0436454ae38ff4f12b43353631
- Source dataset
- uspto-grants-2011_04
- Patent number
- US07919507B2
Reaction notes
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