tert-Butyl (2S)-2-(aminomethyl)piperidine-1-carboxylate → (S)-2-(1,8-Naphthyridin-2-ylamino)methyl-piperidine-1-carboxylic acid tert butyl ester

HRID 2074390Notes

Reaction equation

HRID 2074390 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:14][NH2:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[C:17]1[CH:26]=[CH:25][C:24]2[C:19](=[N:20][CH:21]=[CH:22][CH:23]=2)[N:18]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:14][NH:15][C:17]1[CH:26]=[CH:25][C:24]2[C:19](=[N:20][CH:21]=[CH:22][CH:23]=2)[N:18]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 1502020tert-Butyl (2S)-2-(aminomethyl)piperidine-1-carboxylateHCID 51528382-Chloro-1,8-naphthyridine

Product 1

HCID 86626012(S)-2-(1,8-Naphthyridin-2-ylamino)methyl-piperidine-1-carboxylic acid tert butyl esterYield 70.8%

Procedure

The title compound (0.28 g) was prepared from (S)-2-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester (0.35 g) and 2-chloro-1,8-naphthyridine (0.19 g) according to the method of D30.

Sources & evidence

ORD record
ord-10f5563437d9460a99c65ae2ce8b3810
Source dataset
uspto-grants-2011_04
Patent number
US07919507B2

Reaction notes

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