HRID2074392
反应详情
EQUATION
反应方程式
REACTANTS
反应物
HCID81531
Diisopropylethylamine
C8H19N
HCID1501973
1,1-Dimethylethyl N-[(2S)-2-piperidinylmethyl]carbamate
C11H22N2O2
HCID9886157
Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)
C10H15F6N6OP
HCID23146305
2-(3-Methyl-1,2,4-oxadiazol-5-yl)benzoic acid
C10H8N2O3
PRODUCTS
生成物
CONDITIONS
反应条件
- 温度
- 90 °C
PROCEDURE
实验过程
A mixture of (S)-1-piperidin-2-ylmethyl-carbamic acid tert butyl ester (2.0 g) and 2-(3-methyl-[1,2,4]oxadiazol-5-yl)-benzoic acid (1.9) in dimethylformaide (10 ml containing diisopropylethylamine (2.4 ml) was treated with [O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate] (3.55 g) and stirred at 90° C. for 16 hours. Solvent was removed at reduced pressure and the residue column chromatographed (silica gel, diethyl ether eluant) to give the title compound (3.4 g).
WORKUP
后处理
- customSolvent was removed at reduced pressure
- customthe residue column chromatographed (silica gel, diethyl ether eluant)