tert-Butyl (2S)-2-(aminomethyl)pyrrolidine-1-carboxylate → (S)-2-[(6,7-Difluoro-quinoxalin-2-ylamino)-methyl]-pyrrolidine-1-carboxylic acid tert butyl ester

HRID 2074394Notes

Reaction equation

HRID 2074394 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:13][NH2:14])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[C:16]1[CH:25]=[N:24][C:23]2[C:18](=[CH:19][C:20]([F:27])=[C:21]([F:26])[CH:22]=2)[N:17]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:13][NH:14][C:25]1[CH:16]=[N:17][C:18]2[C:23](=[CH:22][C:21]([F:26])=[C:20]([F:27])[CH:19]=2)[N:24]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 1512533tert-Butyl (2S)-2-(aminomethyl)pyrrolidine-1-carboxylateHCID 103755432-Chloro-6,7-difluoroquinoxaline

Product 1

HCID 86626013(S)-2-[(6,7-Difluoro-quinoxalin-2-ylamino)-methyl]-pyrrolidine-1-carboxylic acid tert butyl esterYield 58.3%

Procedure

The title compound (0.53 g) was prepared from (S)-2-aminomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (0.5 g) and 2-chloro-6,7-difluoroquinoxaline (0.5 g) according to the method of D30.

Sources & evidence

ORD record
ord-6b8390644f6a42b29affb89328749a83
Source dataset
uspto-grants-2011_04
Patent number
US07919507B2

Reaction notes

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