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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 207449Generated: October 29, 2026

Chlorotrimethylsilane → 2-chloro-5-methyl-4-[[3-(trifluoromethyl)phenyl]methyl]pyrimidine

https://huagongshe.com/reaction/207449

Reaction equation

Participants

RoleNameHCIDCharge
ReactantChlorotrimethylsilaneHCID 6397—
Reactant1,2-DibromoethaneHCID 7839—
ReactantTetrahydrofuranHCID 8028—
ReactantTriphenylphosphineHCID 11776—
ReactantZincHCID 23994—
ReactantPalladium ChlorideHCID 24290—
ReactantPyrimidine, 2,4-dichloro-5-methyl-HCID 74508—
Reactant1-(Bromomethyl)-3-(trifluoromethyl)benzeneHCID 123061—
Product2-chloro-5-methyl-4-[[3-(trifluoromethyl)phenyl]methyl]pyrimidineHCID 12056714—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (6/10)
ORD IDord-bd04acbc9e5c4826bc5edc80e0694b6a
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (6/10)