Chlorotrimethylsilane → 2-chloro-5-methyl-4-[[3-(trifluoromethyl)phenyl]methyl]pyrimidine
Reaction equation
[Br:1][CH2:2][CH2:3][Br:4].[CH3:5][Si:6]([Cl:7])([CH3:8])[CH3:9].[Cl:22][c:23]1[n:24][cH:25][c:26]([CH3:30])[c:27]([Cl:29])[n:28]1.[F:10][C:11]([c:12]1[cH:13][c:14]([CH2:15][Br:16])[cH:17][cH:18][cH:19]1)([F:20])[F:21].[O:31]1[CH2:32][CH2:33][CH2:34][CH2:35]1.[Pd:37]([Cl:38])[Cl:39].[Zn:36].[c:40]1([P:41]([c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)[c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)[cH:54][cH:55][cH:56][cH:57][cH:58]1.[c:59]1([P:60]([c:61]2[cH:62][cH:63][cH:64][cH:65][cH:66]2)[c:67]2[cH:68][cH:69][cH:70][cH:71][cH:72]2)[cH:73][cH:74][cH:75][cH:76][cH:77]1>>[F:10][C:11]([c:12]1[cH:13][c:14]([CH2:15][c:27]2[c:26]([CH3:30])[cH:25][n:24][c:23]([Cl:22])[n:28]2)[cH:17][cH:18][cH:19]1)([F:20])[F:21]Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-bd04acbc9e5c4826bc5edc80e0694b6a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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