Hydrochloric Acid → 2-[3,5-bis(trifluoromethyl)phenyl]-N-{6-fluoro-6'-[(7 S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-2-methyl-3,4'-bipyridin-3'-yl}-N,2-dimethylpropanamide hydrochloride

HRID 2074916Notes

Reaction equation

HRID 2074916 reaction equation
[ClH:1].[F:2][C:3]([F:48])([F:47])[C:4]1[CH:5]=[C:6]([C:14]([CH3:46])([CH3:45])[C:15]([N:17]([C:19]2[CH:20]=[N:21][C:22]([N:33]3[C@H:42]([CH2:43][OH:44])[CH2:41][N:40]4[C@H:35]([CH2:36][O:37][CH2:38][CH2:39]4)[CH2:34]3)=[CH:23][C:24]=2[C:25]2[C:26]([CH3:32])=[N:27][C:28]([F:31])=[CH:29][CH:30]=2)[CH3:18])=[O:16])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1>>[ClH:1].[F:48][C:3]([F:2])([F:47])[C:4]1[CH:5]=[C:6]([C:14]([CH3:45])([CH3:46])[C:15]([N:17]([C:19]2[CH:20]=[N:21][C:22]([N:33]3[C@H:42]([CH2:43][OH:44])[CH2:41][N:40]4[C@H:35]([CH2:36][O:37][CH2:38][CH2:39]4)[CH2:34]3)=[CH:23][C:24]=2[C:25]2[C:26]([CH3:32])=[N:27][C:28]([F:31])=[CH:29][CH:30]=2)[CH3:18])=[O:16])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 160639112-[3,5-Bis(trifluoromethyl)phenyl]-n{6-fluoro-6'-[(7s,9as)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1h)-yl]-2-methyl-3,4'-bipyridin-3'-yl}-n,2-dimethylpropanamide

Product 1

HCID 160639122-[3,5-bis(trifluoromethyl)phenyl]-N-{6-fluoro-6'-[(7 S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-2-methyl-3,4'-bipyridin-3'-yl}-N,2-dimethylpropanamide hydrochloride

Procedure

HCl salt made as described in example 41 starting from 2-[3,5-bis(trifluoromethyl)phenyl]-N-{6-fluoro-6′-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-2-methyl-3,4′-bipyridin-3′-yl}-N,2-dimethylpropanamide (E43, 11.3 mg) to afford an off white solid.

Workup

  1. customto afford an off white solid

Sources & evidence

ORD record
ord-7d9dc76647b64cb2b556187085e73de0
Source dataset
uspto-grants-2011_04
Patent number
US07919491B2

Reaction notes

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