Hydrochloric Acid → 2-[3,5-bis(trifluoromethyl)phenyl]-N-{6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-4-[2-(hydroxymethyl)phenyl]-3-pyridinyl}-N,2-dimethylpropanamide hydrochloride

HRID 2074922Notes

Reaction equation

HRID 2074922 reaction equation
[ClH:1].[F:2][C:3]([F:48])([F:47])[C:4]1[CH:5]=[C:6]([C:14]([CH3:46])([CH3:45])[C:15]([N:17]([C:19]2[CH:20]=[N:21][C:22]([N:33]3[C@H:42]([CH2:43][OH:44])[CH2:41][N:40]4[C@H:35]([CH2:36][O:37][CH2:38][CH2:39]4)[CH2:34]3)=[CH:23][C:24]=2[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[CH2:31][OH:32])[CH3:18])=[O:16])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1>>[ClH:1].[F:48][C:3]([F:2])([F:47])[C:4]1[CH:5]=[C:6]([C:14]([CH3:45])([CH3:46])[C:15]([N:17]([C:19]2[CH:20]=[N:21][C:22]([N:33]3[C@H:42]([CH2:43][OH:44])[CH2:41][N:40]4[C@H:35]([CH2:36][O:37][CH2:38][CH2:39]4)[CH2:34]3)=[CH:23][C:24]=2[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[CH2:31][OH:32])[CH3:18])=[O:16])[CH:7]=[C:8]([C:10]([F:11])([F:12])[F:13])[CH:9]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 160639512-[3,5-bis(trifluoromethyl)phenyl]-N-{6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-4-[2-(hydroxymethyl)phenyl]-3-pyridinyl}-N,2-dimethylpropanamide

Product 1

HCID 160639962-[3,5-bis(trifluoromethyl)phenyl]-N-{6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-4-[2-(hydroxymethyl)phenyl]-3-pyridinyl}-N,2-dimethylpropanamide hydrochloride

Procedure

HCl salt made according to method described in Example 41 starting from 2-[3,5-bis(trifluoromethyl)phenyl]-N-{6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-4-[2-(hydroxymethyl)phenyl]-3-pyridinyl}-N,2-dimethylpropanamide (E49, 10.2 mg) to afford a yellow solid.

Workup

  1. customto afford a yellow solid

Sources & evidence

ORD record
ord-2155b039196d49b5bb1315cda47d8563
Source dataset
uspto-grants-2011_04
Patent number
US07919491B2

Reaction notes

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