Tert-Butylamine → HCID 10887913, compound

HRID 2074958Notes

Reaction equation

HRID 2074958 reaction equation
[C:1]([NH2:5])([CH3:4])([CH3:3])[CH3:2].S([O-])([O-])(=O)=O.[Mg+2].[CH:12](=O)[CH:13]([CH3:15])[CH3:14]>CCOCC>[CH3:12][CH:13]([CH3:15])[CH:14]=[N:5][C:1]([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 6385Tert-ButylamineHCID 6561IsobutyraldehydeHCID 24083Sulfuric acid magnesium salt (1:1)

Product 1

HCID 10887913HCID 10887913, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a stirred solution of t-butylamine (20.0 mL, 190 mmol) in anhydrous ether (200 mL) was added magnesium sulfate (20 g). A solution of isobutyraldehyde (17.3 mL, 190 mmol) in ether (50 mL) was then added dropwise over 30 minutes. After stirring at ambient temperature for 3 days, the reaction was filtered and the ether removed in vacuo (300 mm). The residual liquid was distilled to afford the title compound (14.0 g, 58%) as a colorless liquid; bp 52° C. (75 mm);

Workup

  1. filtrationthe reaction was filtered
  2. customthe ether removed in vacuo (300 mm)
  3. distillationThe residual liquid was distilled

Sources & evidence

ORD record
ord-9bf0708685984d138af65f7a0a62c323
Source dataset
uspto-grants-2011_04
Patent number
US07919523B2

Reaction notes

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