Hydrazine hydrate (1:1) → HCID 45080062, compound

HRID 2074974Notes

Reaction equation

HRID 2074974 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH3:9])=[CH:4][N:3]=1.O.[NH2:11][NH2:12]>CO>[NH:11]([C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH3:9])=[CH:4][N:3]=1)[NH2:12]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 35727632-Chloro-5-ethylpyrimidine

Product 1

HCID 45080062HCID 45080062, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of 2-chloro-5-ethylpyrimidine (0.31 g, 2.2 mmol) in MeOH (5 mL) was added hydrazine monohydrate (1.0 mL, 20.6 mmol). After stirring for 16 h at 50° C., the solution was cooled to room temperature and purified by reverse phase HPLC to give 0.24 g (80%) of the title compound as a white solid. MH+139.

Workup

  1. temperaturethe solution was cooled to room temperature
  2. custompurified by reverse phase HPLC

Sources & evidence

ORD record
ord-3fe2d176ee194323bdc001f715cb9153
Source dataset
uspto-grants-2011_04
Patent number
US07919528B2

Reaction notes

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