反应详情

A solution of 3-azidomethyl-5-trifluoromethyl-benzonitrile (140 mg, 0.619 mmol) in THF (1 ml) was treated with trimethyl phosphine (94.2 mg, 1.24 mmol) at room temperature and stirred for 2 hours. Reaction was quenched with water and stirred for 30 minutes. Reaction was extracted with ethyl ether and organic layer was dried over anhydrous magnesium sulphate and concentrated in vacuo. The crude product (70 mg, 56%) was used without further purification. 1H NMR (400 MHz, CDCl3) δ ppm 1.64 (s, 2H) 3.98 (s, 2H) 7.74 (s, 1H) 7.83 (s, 2H).

1. customReaction
2. customwas quenched with water
3. stirringstirred for 30 minutes
4. customReaction
5. extractionwas extracted with ethyl ether and organic layer
6. dry with materialwas dried over anhydrous magnesium sulphate
7. concentrationconcentrated in vacuo
8. customThe crude product (70 mg, 56%) was used without further purification