Methyl iodide → HCID 58968720, compound

HRID 2075107Notes

Reaction equation

HRID 2075107 reaction equation
[CH:1]1([CH2:6][C:7]([C:11]2[CH:39]=[CH:38][C:37]([C:40]([F:43])([F:42])[F:41])=[CH:36][C:12]=2[CH2:13][N:14]([CH2:21][C:22]2[CH:27]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:25]=[C:24]([C:32]([F:35])([F:34])[F:33])[CH:23]=2)[C:15]2[N:16]=[N:17][N:18]([CH3:20])[N:19]=2)([O:9][CH3:10])[CH3:8])[CH2:5][CH2:4][CH2:3][CH2:2]1.F[C:45](F)(F)C1C=CC(C#N)=CC=1.C1([Mg]Br)CCCCC1.C([Mg]Br)C.CI>>[CH:6]1([C:7]([C:11]2[CH:39]=[CH:38][C:37]([C:40]([F:41])([F:42])[F:43])=[CH:36][C:12]=2[CH2:13][N:14]([CH2:21][C:22]2[CH:23]=[C:24]([C:32]([F:33])([F:35])[F:34])[CH:25]=[C:26]([C:28]([F:31])([F:29])[F:30])[CH:27]=2)[C:15]2[N:16]=[N:17][N:18]([CH3:20])[N:19]=2)([O:9][CH3:10])[CH2:8][CH3:45])[CH2:1][CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

6

Reactant 5

HCID 6328Methyl iodideHCID 67995Benzonitrile, 4-(trifluoromethyl)-HCID 58968691HCID 58968691, compoundHCID 178418443HCID 178418443, compoundHCID 178419651HCID 178419651, compound

Product 1

HCID 58968720HCID 58968720, compound

Procedure

This compound was prepared by an analogous series of reactions to that used for the preparation of N-(2-(1-cyclopentyl-2-methoxypropan-2-yl)-5-(trifluoromethyl)benzyl)-N-(3,5-bis(trifluoromethyl)benzyl)-2-methyl-2H-tetrazol-5-amine from 2-((3,5-bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazole-5-yl)amino)methyl)-4-(trifluoromethyl)benzonitrile by the addition of cyclohexylmagnesium bromide followed by ethylmagnesium bromide then alkylation with methyl iodide. LC-MS calc 637.5, found 638.5 (M+H).

Workup

  1. customThis compound was prepared by an analogous series of reactions to

Sources & evidence

ORD record
ord-a332a341184f4ad3b8cf257d9004ee8b
Source dataset
uspto-grants-2011_04
Patent number
US07919506B2

Reaction notes

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