Methanol → Ethyl 1-(4-bromo-3-fluorobenzyl)azetidine-3-carboxylate

HRID 2075182Notes

Reaction equation

HRID 2075182 reaction equation
[Br:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][N:7]2[CH2:10][CH:9]([C:11]([O:13][CH3:14])=[O:12])[CH2:8]2)=[CH:4][C:3]=1[F:17].[CH3:18]O>>[Br:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][N:7]2[CH2:10][CH:9]([C:11]([O:13][CH2:14][CH3:18])=[O:12])[CH2:8]2)=[CH:4][C:3]=1[F:17]

Participants

3

Reactant 2

HCID 887MethanolHCID 59651823Methyl 1-(4-bromo-3-fluorobenzyl)azetidine-3-carboxylate

Product 1

HCID 58415312Ethyl 1-(4-bromo-3-fluorobenzyl)azetidine-3-carboxylate

Procedure

Synthesized in an analogous fashion as methyl 1-(4-bromo-3-fluorobenzyl)azetidine-3-carboxylate, but MeOH from step 1 was removed and EtOH was used for step 2. MS (ESI) m/z: Calculated: 315.0; Observed: 316.0 (M++1).

Workup

  1. customwas removed

Sources & evidence

ORD record
ord-bc425bd5c7644e62b713f18be6616752
Source dataset
uspto-grants-2011_04
Patent number
US07919519B2

Reaction notes

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