反应详情

温度

0 °C

To a solution of benzofuran-5-yl(phenyl)methanol (4.0 g, 18 mmol) and triethylamine (7.3 mL, 54 mmol) in 30 mL 1:1 DCM/DMSO under nitrogen at 0° C. was added a solution of SO3*py (8.5 g, 54 mmol) in 20 mL DMSO dropwise via addition funnel. The reaction was allowed to stir 5 h at 0° C. and was quenched by addition of water and 250 mL Et2O. The organic layer was washed with water, 1N HCl, 1N NaOH, brine, and was dried over sodium sulfate, filtered, and concentrated. The resulting solid benzofuran-5-yl(phenyl)methanone was used without further purification. MS (ESI) m/z: Calculated: 222.1; Observed: 223.0 (M++1).

1. additiondropwise via addition funnel
2. customwas quenched by addition of water and 250 mL Et2O
3. washThe organic layer was washed with water, 1N HCl, 1N NaOH, brine
4. dry with materialwas dried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated
7. customThe resulting solid benzofuran-5-yl(phenyl)methanone was used without further purification