Methyl 1-(3-bromobenzyl)azetidine-3-carboxylate → Methyl 1-(3-(5-benzylbenzofuran-2-yl)benzyl)azetidine-3-carboxylate

HRID 2075213Notes

Reaction equation

HRID 2075213 reaction equation
[CH2:1]([C:8]1[CH:9]=[CH:10][C:11]2[O:15][C:14](B(O)O)=[CH:13][C:12]=2[CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[C:21]1[CH:22]=[C:23]([CH:33]=[CH:34][CH:35]=1)[CH2:24][N:25]1[CH2:28][CH:27]([C:29]([O:31][CH3:32])=[O:30])[CH2:26]1>>[CH2:1]([C:8]1[CH:9]=[CH:10][C:11]2[O:15][C:14]([C:21]3[CH:22]=[C:23]([CH:33]=[CH:34][CH:35]=3)[CH2:24][N:25]3[CH2:28][CH:27]([C:29]([O:31][CH3:32])=[O:30])[CH2:26]3)=[CH:13][C:12]=2[CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 58415353Methyl 1-(3-bromobenzyl)azetidine-3-carboxylateHCID 59595866HCID 59595866, compound

Product 1

HCID 58415396Methyl 1-(3-(5-benzylbenzofuran-2-yl)benzyl)azetidine-3-carboxylate

Procedure

Synthesized according to Scheme B2, Step 2 and general procedure F from 5-benzylbenzofuran-2-ylboronic acid and methyl 1-(3-bromobenzyl)azetidine-3-carboxylate to give methyl 1-(3-(5-benzylbenzofuran-2-yl)benzyl)azetidine-3-carboxylate as a light yellow oil. MS (ESI) m/z: Calculated: 411.2; Observed: 412 (M++1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-920d40db4a5241aeb6e4b4fe8809131f
Source dataset
uspto-grants-2011_04
Patent number
US07919519B2

Reaction notes

Loading…