反应详情

温度

140 °C

5-Benzyl-2-methoxypyridine (2.6 g, 13 mmol) in 15 mL AcOH was added 15 mL 48% HBr. The mixture was heated to 140° C. for 3 h, cooled and poured onto ice. The mixture was basified to pH 6-7 and the resulting solid was collected by filtration, rinsed with water, and dried in vacuo to give 5-benzylpyridin-2-ol as an off-white solid. MS (ESI) m/z: Calculated: 185.1; Observed: 186.0 (M++1).

1. temperaturecooled
2. additionpoured onto ice
3. filtrationthe resulting solid was collected by filtration
4. washrinsed with water
5. customdried in vacuo