反应详情

The above mentioned tert-butyl (S)-1-(5-(3-(methylamino)-4-nitrophenyl)-1,3,4-thiadiazol-2-yl-boc-amino)-3-(4-(trifluoromethyl)phenyl)propan-2-ylcarbamate (1.13 g, 2 mmol) was dissolved in 200 mL MeOH in a 500 mL round bottle flask. To this flask, was added 10% Pd/C 100 mg pre-wet with water and 2 mL acetic acid. The mixture was stirred under an atmosphere of hydrogen under balloon pressure for 1 hour. After filtration through a pad of celite, the solution was evaporated to dryness. The residue was re-dissolved in 200 mL of EtOAc. The solution was washed with saturated sodium bicarbonate three times and dried over sodium sulfate. The product was obtained after removing the solvent. It was used directly in the next step.

1. filtrationAfter filtration through a pad of celite
2. customthe solution was evaporated to dryness
3. dissolutionThe residue was re-dissolved in 200 mL of EtOAc
4. washThe solution was washed with saturated sodium bicarbonate three times
5. dry with materialdried over sodium sulfate
6. customThe product was obtained
7. customafter removing the solvent