HCID 57950708, compound → HCID 57950517, compound

HRID 2075398Notes

Reaction equation

HRID 2075398 reaction equation
CC1(C)OC(=O)[CH:5]([CH2:9][C@@H:10]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])[CH2:11][C:12]2[CH:13]=[N:14][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:16][CH:17]=2)[C:4](=[O:30])O1>C1(C)C=CC=CC=1>[O:30]=[C:4]1[CH2:5][CH2:9][C@H:10]([CH2:11][C:12]2[CH:13]=[N:14][C:15]([C:18]([F:19])([F:21])[F:20])=[CH:16][CH:17]=2)[N:22]1[C:23]([O:24][C:25]([CH3:28])([CH3:26])[CH3:27])=[O:29]

Participants

3

Reactant 1

HCID 57950708HCID 57950708, compound

Product 1

HCID 57950517HCID 57950517, compoundYield 67.4%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

(R)-tert-Butyl 3-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-1-(6-(trifluoromethyl)pyridin-3-yl)propan-2-ylcarbamate (2.5 g, 5.6 mmol) in 100 mL toluene was heated at 105° C. for 8 hours. After removing the solvent, the residue was purified by chromatography on silica gel (20-40% EtOAc in hexane) to provide the product (1.3 g, 67%) as a white solid. LCMS (API-ES) m/z (%): 345.0 (100%, M+H+).

Workup

  1. customAfter removing the solvent
  2. customthe residue was purified by chromatography on silica gel (20-40% EtOAc in hexane)

Sources & evidence

ORD record
ord-6ab0efeedea44488b094873f328d0479
Source dataset
uspto-grants-2011_04
Patent number
US07919504B2

Reaction notes

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