HCID 57950708, compound → HCID 57950517, compound

Participants

Reaction Steps

(R)-tert-Butyl 3-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-1-(6-(trifluoromethyl)pyridin-3-yl)propan-2-ylcarbamate (2.5 g, 5.6 mmol) in 100 mL toluene was heated at 105° C. for 8 hours. After removing the solvent, the residue was purified by chromatography on silica gel (20-40% EtOAc in hexane) to provide the product (1.3 g, 67%) as a white solid. LCMS (API-ES) m/z (%): 345.0 (100%, M+H+).

Provenance & Evidence