Hydrochloric Acid → N,N-dimethyl-5-[(2'-oxospiro[6H-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)methyl]-2-(trifluoromethyl)furan-3-carboxamide

HRID 207541Notes

Reaction equation

HRID 207541 reaction equation
[CH3:2][NH:3][CH3:4].[CH3:5][C:6]([CH3:7])([CH3:8])[CH2:9][CH2:10][NH2:11].[ClH:1].[O:12]=[C:13]1[N:14]([CH2:33][c:34]2[cH:35][c:36]([C:43](=[O:44])[OH:45])[c:37]([C:39]([F:40])([F:41])[F:42])[o:38]2)[c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[C:21]12[CH2:22][O:23][c:24]1[c:25]2[cH:26][c:27]2[c:28]([cH:32]1)[O:29][CH2:30][O:31]2.[O:46]=[C:47]1[C:48]2([CH2:49][O:50][c:51]3[cH:52][c:53]4[c:54]([cH:55][c:56]32)[CH2:57][CH2:58][O:59]4)[c:60]2[c:61]([cH:62][cH:63][cH:64][cH:65]2)[N:66]1[CH2:67][C:68]([OH:69])=[O:70]>>[CH3:2][N:3]([CH3:4])[C:43]([c:36]1[cH:35][c:34]([CH2:33][N:14]2[C:13](=[O:12])[C:21]3([c:20]4[c:15]2[cH:16][cH:17][cH:18][cH:19]4)[CH2:22][O:23][c:24]2[c:25]3[cH:26][c:27]3[c:28]([cH:32]2)[O:29][CH2:30][O:31]3)[o:38][c:37]1[C:39]([F:40])([F:41])[F:42])=[O:45]

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 674DimethylamineHCID 197093,3-DimethylbutylamineHCID 59263485(2'-oxo-5,6-dihydrospiro[benzo[1,2-b:5,4-b']difuran-3,3-indol]-1'(2'H)-yl)acetic acidHCID 685965505-((2'-oxo-6H-spiro[benzofuro[6,5-d][1,3]dioxole-7,3'-indoline]-1'-yl)methyl)-2-(trifluoromethyl)furan-3-carboxylic acid

Product 1

HCID 59352465N,N-dimethyl-5-[(2'-oxospiro[6H-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-1'-yl)methyl]-2-(trifluoromethyl)furan-3-carboxamide

Sources & evidence

ORD record
ord-3ce86f2e0443463f979e1ce309dcbcc6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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