HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 4-(4-Nitropyridin-2-yl)morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 4-Nitropyridine | HCID 70734 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(4-Nitropyridin-2-yl)morpholine | HCID 57418546 | 56.5% |
Reaction Steps
To a solution of 2-chloro, 4-nitropyridine (0.2 g, 1.27 mmol) in THF (3 mL) was added morpholine (328 mg, 38.1 mmol). The reaction was heated to 80 C and stirred overnight. The solvent was evaporated and the residue purified by column chromatography (2/1 Hex/EtOAc) to yield 150 mg of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919617B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-36c9a65afa0142cd9b3d504a40cb6217 |
| Source note | uspto-grants-2011_04 |