HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 4-tert-Butyl-2-morpholin-4-ylmethyl-6-nitro-phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Phenol, 4-(1,1-dimethylethyl)-2-nitro- | HCID 18661 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-tert-Butyl-2-morpholin-4-ylmethyl-6-nitro-phenol | HCID 57503077 | — |
Reaction Steps
A solution of 4-t-butyl-2-nitro-phenol (980 mg, 5 mmol), morpholine (50 mmol) and paraformaldehyde (1.5 g, 50 mmol) in 20 mL ethanol was heated in a sealed vial at 95° C. for 6 hr. After removal of the solvent and morpholine, the residue was purified via silica gel column chromatography to afford 1.75 g target compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919617B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-1b2ca52609b54814a4be58679fdecb5a |
| Source note | uspto-grants-2011_04 |