反应详情

温度

80 °C

To 6-Bromo-2-methyl-quinoline (2.4 g, 11.0 mmol) in benzene (20 mL) at room temperature was added NCS (1.44 g, 11.0 mmol) and catalytic benzoyl peroxide, and the reaction was heated to 80° C. for 1 hour. After cooling to room temperature, the mixture was concentrated and purified by silica gel chromatography (0-50% EtOAc in hexanes) to give the desired product, 4a.

1. temperatureAfter cooling to room temperature
2. concentrationthe mixture was concentrated
3. custompurified by silica gel chromatography (0-50% EtOAc in hexanes)