HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → N-(6-Bromo-quinolin-2-ylmethyl)-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (6-Bromoquinolin-2-YL)methanamine | HCID 57365264 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(6-Bromo-quinolin-2-ylmethyl)-acetamide | HCID 67091079 | — |
Reaction Steps
To a slurry of 4b (401 mg, 1.7 mmol) in CH2Cl2 at room temperature was added NEt3 (0.47 mL, 3.4 mmol), followed by acetyl chloride (0.18 mL, 2.6 mmol). Once the reaction was complete by LCMS analysis, the mixture was concentrated and purified by silica gel chromatography (0-100% EtOAc in hexanes, followed by 10% MeOH in EtOAc) to give the desired product, 4c.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919621B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-79e60b44f3d14657b94e83c31a15ac05 |
| Source note | uspto-grants-2011_04 |