反应详情

温度

80 °C

To (7-Iodo-4-phenyl-quinolin-2-yl)-hydrazine (400 mg, 1.1 mmol) in EtOH (5 mL) was added trimethyl orthoacetate (2 mL), and the reaction was heated to 80° C. overnight. After cooling to room temperature, the mixture was concentrated and purified by silica gel chromatography (40-100% EtOAc in hexanes) to give the desired product, 5u.

1. temperatureAfter cooling to room temperature
2. concentrationthe mixture was concentrated
3. custompurified by silica gel chromatography (40-100% EtOAc in hexanes)