HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2075698Generated: October 30, 2026
Trimethyl orthoacetate → 8-Iodo-1-methyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinoline
https://huagongshe.com/reaction/2075698
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trimethyl orthoacetate | HCID 15050 | — |
| Reactant | HCID 67090996 | HCID 67090996 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 8-Iodo-1-methyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinoline | HCID 67091012 | — |
Reaction Steps
To (7-Iodo-4-phenyl-quinolin-2-yl)-hydrazine (400 mg, 1.1 mmol) in EtOH (5 mL) was added trimethyl orthoacetate (2 mL), and the reaction was heated to 80° C. overnight. After cooling to room temperature, the mixture was concentrated and purified by silica gel chromatography (40-100% EtOAc in hexanes) to give the desired product, 5u.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07919621B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-b08166077181491a88a1f5d236b5e3ea |
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| Source note | uspto-grants-2011_04 |
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