反应详情

温度

140 °C

6-Bromo-2-chloro-quinoline (3.34 g, 13.8 mmol) was dissolved in p-methoxybenzylamine (5 mL) and heated to 140° C. for 1 hour. The mixture was cooled to room temperature, filtered, and concentrated. The residue was purified by silica gel chromatography, and the isolated material was refluxed in TFA (6 mL) for 1 hour. The mixture was concentrated and purified by silica gel chromatography to give the desired product, 8a.

1. temperatureThe mixture was cooled to room temperature
2. filtrationfiltered
3. concentrationconcentrated
4. customThe residue was purified by silica gel chromatography
5. temperaturethe isolated material was refluxed in TFA (6 mL) for 1 hour
6. concentrationThe mixture was concentrated
7. custompurified by silica gel chromatography